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Selenium, SeMetabolism absorbed in the upper GI tract Functions involved in glutathione peroxidase synthesis HPETE -> HETE, instead of leukotrienes leukotrienes increases production of mucus leukotrienes contract smooth muscle in the lungs may inhibit several forms of cancer inhibits reverse transcriptase, inhibits viral replication increases cytotoxicity of killer T cells, potentiates interleukin 2 anti-clotting Requirements RDA - 55-70 mcg qd, ODI - 200-300 mcg qd Sources Brazil nuts, snapper, halibut Deficiency Keshan disease - cardiomyopathy caused by deficiency Kashin-Beck disease - arthritis caused by deficiency Duchenne's muscular dystrophy - increased excretion Toxicity selenium has a narrow margin of safety garlic breath and sweat, metallic taste in mouth N/V, weight loss, GI irritation depression, nervousness, emotional instability hair loss, fingernail damage Therapeutics EENT cataracts - cofactor for glutathione peroxidase macular degeneration - cofactor for glutathione peroxidase Respiratory asthma - decreases leukotriene synthesis from arachadonic acid cystic fibrosis Cardiac cardiovascular disease - with vitamin E Liver detoxification - involved in glutathione peroxidase synthesis heavy metal toxicity Immune allergies viral infection - selenoprotein inhibits viral replication HIV - inhibits reverse transcriptase herpes, molluscom contagiosum, polio - inhibits viral replication immunity - potentiates interleukin 2 Musculoskeletal Osgood-Schlatter disease - with vitamin E muscular dystrophy - increases secretion associated with Dechenne's arthritis, inflammatory disease - anti-inflammatory Oncology chemotherapy protection - involved in glutathione peroxidase synthesis cancer prevention - increases cytotoxicity of killer T cells
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Fantastic new books! CAM Therapies has studies on natural therapies for over 100 diseases. CAM Labs lists lab tests for 100 diseases. Nutritional Genetics is a fantastic resource.
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