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| Chlorpropamide, Diabinese Description Chlorpropamide is a sulphonylurea drug used to treat type 2 diabetes mellitus. Action antidiabetic, sulfonurease Indications diabetes mellitus, Side Effects abdominal pain, agranulocytosis, anemia, aplastic anemia, bullous rash, cholestasis, constipation, diarrhea, dyspepsia, exfoliative dermatitis, glomerulonephritis, headache, hemolysis, hypoglycemia, jaundice, leukopenia, maculopapular rash, nausea/vomiting, nephrotic syndrome, pancytopenia, paresthesias, photosensitivity, porphyria, SIADH, Stevens-Johnson syndrome, thrombocytopenia, toxic epidermal necrolysis, urticaria, Drug-Vitamin-Herb Interactions Negative interactions: Ipriflavone Ipriflavone may increase the effects of antidiabetics which may cause hypoglycemia. Potassium citrate Potassium citrate may decrease levels of sulfonylurea antidiabetic drugs. St JohnÕs Wort and Dong quai St JohnÕs Wort and Dong quai may cause sensitivity to the sun, adding to side effect of antidiabetics. Mixed interactions: Chromium Chromium improves blood sugar control, which may cause hypoglycemia with antidiabetic agents. Ginseng Ginseng lowers blood sugar levels, which may cause hypoglycemia with antidiabetic agents. Magnesium Diabetes may cause low levels of magnesium. Magnesium Magnesium increases the absorption of sulfonylurea antidiabetics. Magnesium Magnesium lowers blood sugar levels, which may cause hypoglycemia if used with antidiabetic agents. Vanadium Vanadium has an insulin-like action, which may cause hypoglycemia if used with antidiabetic agents. Vitamin E Antidiabetic supplements - Lipoic acid, Carnitine Antibiabetic Herbs: Aloe, Bitter mellon, Bilberry, Burdock, Dandelion, Fenugreek, Garlic, Gymnema Antibiabetic herbs may cause hypoglycemia if used with antidiabetic agents. Antibiabetic Supplements: Lipoic acid, Carnitine Antibiabetic supplements may cause hypoglycemia if used with antidiabetic agents. Positive interactions: Calcium Calcium corrects vitamin B12 malabsorption caused by metformin and phenformin. Coenzyme Q10 Antidiabetic drugs interfere with the activity of enzymes containing CoQ10. Vitamin B12 Metformin and phenformin cause malabsorption of vitamin B12.
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