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Clomipramine, Anafranil Description Clomipramine is a tricyclic antidepressant Action tricyclic antidepressant Indications Side Effects abdominal pain, adynamic ileus, agranulocytosis, anemia, anorexia, anxiety, blurred vision, breast enlargement, confusion, constipation, cycloplegia, diarrhea, dizziness, drowsiness, EEG changes, ejaculation dysfunction, eosinophilia, erythema, fever, galactorrhea, gynecomastia, heart failure, hypertension, impotence, increased intraocular pressure, jaundice, leukopenia, libido decrease, mydriasis, myocardial infarction, nausea/vomiting, orgasm dysfunction, orthostatic hypotension, palpitations, parkinsonism, photosensitivity, PR prolongation, pruritus, purpura, QT prolongation, sedation, seizures, SIADH, stroke, testicular swelling, thrombocytopenia, tremor, urinary retention, urticaria, vasculitis, ventricular tachycardia, withdrawal, xerostomia, Drug-Vitamin-Herb Interactions Negative interactions: Sedative herbs: Kava, Passionflower, Hops, Ashwagandha, Calendula, Catnip, LadyÕs Slipper, Lemon Balm, Sassafras, Skullcap, and Yerba mansa. Sedative herbs may cause excess sedation when used with tricyclic antidepressants. St JohnÕs Wort and Dong quai St JohnÕs Wort and Dong quai may cause sensitivity to sunlight, adding to side effect of tricyclic antidepressants. 5-HTP 5-HTP increases levels of serotonin, which increases the risk of serotonin syndrome. SAMe SAMe increases levels of serotonin, which increases the risk of serotonin syndrome. St JohnÕs Wort St JohnÕs Wort may increase levels of serotonin, which increases the risk of serotonin syndrome. Mixed interactions: Grapefruit Juice Grapefruit Juice slows breakdown of several drugs, including tricyclic clomipramine. Positive interactions: Coenzyme Q10 Tricyclic antidepressants may interfere with enzymes containing CoQ10.
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