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| Ethotoin, Peganone Description Ethotoin is an anti-convulsant drug used in the treatment of epilepsy. Ethotoin is a hydantoin, similar to phenytoin. It lacks phenytoin's side effects of gingival hyperplasia and hirsutism, but is less effective. Ethotoin is no longer widely used. Action anticonvulsant Indications Pain Side Effects Nystagmus, ataxia, dysarthria, slurred speech, mental confusion, dizziness, nausea/vomiting, diarrhea, constipation, hepatic damage, rashes, thrombocytopenia, leukopenia, agranulocytopenia, agranulocytosis, pancytopenia, coarsening of the facial features, enlargement of lips, polyarthropathy, hyperglycemia, weight gain., Drug-Vitamin-Herb Interactions Negative interactions: Ginkgo biloba Ginkgo leaves contain small amounts of a natural nerve toxin. Glutamine Glutamine forms glutamate which acts as a neurotransmitter. Grapefruit juice Grapefruit juice slows the breakdown of several drugs, including carbamezapine. Ipriflavone Ipriflavone - inhibits breakdown of carbamezapine and phenytoin, may cause toxic build up Sedative herbs (Kava, Valerian, Hops) Sedative herbs may add to depressant side-effect of anticonvulsants. Niacinamide Nicotinamide (Niacinamide) increases levels of carbamezapine and primidone, which may cause a toxic build up. St JohnÕs Wort and Dong Quai St JohnÕs Wort and Dong Quai may add to side effect of sun sensitivity. Vitamin A Valproic acid may interfere with the ability to handle vitamin A (beta carotene is fine). White willow High doses of aspirin increases phenytoin levels and toxicity. White willow contains salicylates (theoretical effect). Folate High levels of folate may increase breakdown of phenytoin (which may cause excess seizures) Mixed interactions: Biotin Anticonvulsants may deplete biotin by competeing for absorption. Take at different times of the day. Folate Anticonvulsants deplete folate. Positive interactions: Calcium Anticonvulsants impair calcium absorption. Take at different times of the day. Carnitine Anticonvulsants (especially valproic acid) deplete carnitine. Vitamin D Anticonvulsants may interfere with vitamin D activity and cause deficiency. Vitamin K Anticonvulsants speed up breakdown of vitamin K, leading to deficiency and bleeding.
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Fantastic new books! CAM Therapies has studies on natural therapies for over 100 diseases. CAM Labs lists lab tests for 100 diseases. Nutritional Genetics is a fantastic resource.
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