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| Methotrexate, Folex PFS, Immunex, Rheumatrex Description anti-neoplastic, immunosuppressant folic acid analog, inhibits human dihydrofolate reductase cytotoxic - inhibits DNA synthesis in the S-phase inhibits replication and function of T cells Action anti-neoplastic, folic acid analog Indications acute lymphocytic leukemia (ALL), asthma, biliary cirrhosis, bladder carcinoma, breast carcinoma, Burkitt's lymphoma, carcinomatous meningitis, choriocarcinoma, Crohn's disease, dermatomyositis, graft-versus-host disease, hydatidiform mole, mycosis fungoides, non-Hodgkin's lymphoma, osteogenic sarcoma, ovarian carcinoma, polymyositis, pregnancy termination, pruritus, psoriasis, rheumatoid arthritis, sarcoidosis, squamous cell carcinoma of the head and neck, Side Effects alopecia, anemia, anorexia, arachnoiditis, azotemia, cirrhosis, crystalluria, diarrhea, elevated hepatic enzymes, GI bleeding, GI perforation, gingivitis, glossitis, hematemesis, hematuria, leukoencephalopathy, leukopenia, nausea/vomiting, neutropenia, ocular irritation, pancytopenia, paresis, pharyngitis, photosensitivity, pruritus, pulmonary fibrosis, renal intratubular obstruction, stomatitis, thrombocytopenia, urticaria, Drug-Vitamin-Herb Interactions Negative interactions: Potassium citrate Potassium citrate (and other citrates) make urine less acidic, which decreases levels of methotrexate. St JohnÕs Wort St JohnÕs Wort may cause sensitivity to sunlight, adding to the side effects of many drugs. Dong Quai Dong Quai may cause sensitivity to sunlight, adding to the side effects of many drugs. White Willow Salicylates may increase methotrexate levels and toxicity. Positive interactions: Folate Folate decreases side effects and increases efficacy in those with arthritis or psoriasis.
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Fantastic new books! CAM Therapies has studies on natural therapies for over 100 diseases. CAM Labs lists lab tests for 100 diseases. Nutritional Genetics is a fantastic resource.
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