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| Olanzapine, Zyprexa, Zydis Description Olanzapine was the second atypical antipsychotic approved by the FDA. Action atypical antipsychotic Indications Olanzapine has been approved by the FDA for the treatment of schizophrenia, acute mania in bipolar disorder, agitation associated with schizophrenia and bipolar disorder, and as maintenance treatment in bipolar disorder and psychotic depression. Side Effects drowsiness was the most frequent ADR (50%) in a small open label trial; extrapyramidal reactions and degree of hyperprolactinemia appear to be low; agranulocytosis has not yet been reported. Drug-Vitamin-Herb Interactions Negative interactions: Kava Kava may block dopamine worsening movement disorder side effects, may cause excess sedation. Phenylalanine Phenylalanine may worssen the side effect of tardive dyskinesia associated with antipsychotic medications. St JohnÕs Wort St JohnÕs Wort accelerates breakdown of olanzapine (Zyprexa) and clozapine (Clozaril). St JohnÕs Wort and Dong quai St JohnÕs Wort and Dong quai can cause sensitivity to sun, adding to the side effects of antipsychotic agents. Sedative herbs: Kava, Passionflower, Hops, Ashwagandha, Calendula, Catnip, LadyÕs Slipper, Lemon Balm, Sassafras, Skullcap, and Yerba mansa. Sedative herbs may cause excess sedation when used with antipsychotic agents. Yohimbe Phenothiazines may increase yohimbe toxicity. Positive interactions: Coenzyme Q10 Phenothiazines inhibit enzymes containing CoQ10. Ginkgo biloba Ginkgo may help reduce side effects and increase efficacy of antipsychotic medications. Milk Thistle Milk Thistle may protect the liver against toxicity caused by phenothiazide drugs. Vitamin E Vitamin E may help treat and prevent tardive dyskenisia (a side effect of phenothiazide drugs).
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Fantastic new books! CAM Therapies has studies on natural therapies for over 100 diseases. CAM Labs lists lab tests for 100 diseases. Nutritional Genetics is a fantastic resource.
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