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| Perphenazine, Etrafon, Triavil, Trilafon Description Perphenazine is a piperazinyl phenothiazine antipsychotic drug. Action piperazinyl phenothiazine antipsychotic Indications Perphenazine is a highly potent neuroleptic used for the treatment of psychotic patients (e.g. patients with schizophrenia) and for patients presenting with manic phases of bipolar disorder. Side Effects adynamic ileus, agranulocytosis, akathisia, aplastic anemia, blurred vision, cholestasis, constipation, contact dermatitis, corneal opacification, diaphoresis, dizziness, drowsiness, dystonia, ejaculation dysfunction, eosinophilia, galactorrhea, headache, hyperprolactinemia, hypertension, hyperthermia, hypotension, hypothermia, impotence, insomnia, jaundice, leukocytosis, leukopenia, libido decrease, mastalgia, menstrual irregularity, mydriasis, neuroleptic malignant syndrome, orthostatic hypotension, pancytopenia, parkinsonism, photosensitivity, priapism, QT prolongation, retinopathy, seizures, sinus tachycardia, skin hyperpigmentation, tardive dyskinesia, thrombocytopenia, torsade de pointes, urinary retention, ventricular tachycardia, visual impairment, weight gain, withdrawal, xerostomia, Drug-Vitamin-Herb Interactions Negative interactions: Kava Kava may block dopamine worsening movement disorder side effects, may cause excess sedation. Phenylalanine Phenylalanine may worssen the side effect of tardive dyskinesia associated with antipsychotic medications. St JohnÕs Wort St JohnÕs Wort accelerates breakdown of olanzapine (Zyprexa) and clozapine (Clozaril). St JohnÕs Wort and Dong quai St JohnÕs Wort and Dong quai can cause sensitivity to sun, adding to the side effects of antipsychotic agents. Sedative herbs: Kava, Passionflower, Hops, Ashwagandha, Calendula, Catnip, LadyÕs Slipper, Lemon Balm, Sassafras, Skullcap, and Yerba mansa. Sedative herbs may cause excess sedation when used with antipsychotic agents. Yohimbe Phenothiazines may increase yohimbe toxicity. Positive interactions: Coenzyme Q10 Phenothiazines inhibit enzymes containing CoQ10. Ginkgo biloba Ginkgo may help reduce side effects and increase efficacy of antipsychotic medications. Milk Thistle Milk Thistle may protect the liver against toxicity caused by phenothiazide drugs. Vitamin E Vitamin E may help treat and prevent tardive dyskenisia (a side effect of phenothiazide drugs).
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Fantastic new books! CAM Therapies has studies on natural therapies for over 100 diseases. CAM Labs lists lab tests for 100 diseases. Nutritional Genetics is a fantastic resource.
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