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| Premarin, Conjugated Estrogens Description Premarin (conjugated estrogens tablets) contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant maresÕ urine. Action synthetic estrogens Indications atrophic vaginitis, breast carcinoma, dysfunctional uterine bleeding, hot flashes, hypogonadism, menopausal symptoms, oophorectomy, osteoporosis, ovarian failure, prostate carcinoma, vulvar squamous hyperplasia, Side Effects bleeding, edema, endometrial carcinoma, gynecomastia, headache, hypertension, libido decrease, libido increase, pancreatitis, peripheral edema (swelling of feet and lower legs), rapid weight gain Menstrual irregularities: amenorrhea, breakthrough bleeding (heavier vaginal bleeding between regular menses), menorrhagia (prolonged or heavier menses), spotting (lighter vaginal bleeding between regular menses) Breast symptoms: mastalgia (breast pain or tenderness), breast enlargement (gynecomastia), breast tumors (breast lumps), breast discharge, breast carcinoma Skin symptoms: acne vulgaris, skin irritation and redness (with transdermal system), erythema nodosum, melasma Abdominal symptoms: abdominal pain, abdominal cramping or bloating, anorexia (loss of appetite), nausea, nausea/vomiting, diarrhea Liver and gallblader symptoms: cholecystitis, cholelithiasis (gallstones), elevated hepatic enzymes, hepatitis, hepatoma Eye symptoms: intolerance to contact lenses, keratoconus (conical protrusion of the cornea) Thromboembolism or thrombus formation: severe or sudden headache; sudden loss of coordination; pains in chest, groin, or leg, especially calf; sudden and unexplained shortness of breath; sudden slurred speech; sudden vision changes; weakness or numbness in arm or leg. Drug-Vitamin-Herb Interactions Negative interactions: Androstenedione Androstenedione increases estrogen levels, which may increase the adverse effects of estrogen therapy. Boron Boron may increase estrogen levels, which may increase the adverse effects of estrogen therapy. Dong quai Dong quai contains beta-sitosterol, a phytoestrogen, which may increase the adverse effects of estrogen therapy. Studies, however, do not support this. Grapefruit juice Grapefruit juice slows breakdown of estrogen. Mixed interactions: Ipriflavone Ipriflavone protects bone, but may increase estrogen effect on the uterus. Positive interactions: Calcium and Vitamin D Calcium and Vitamin D aid in bone growth. Magnesium Magnesium metabolism is enhanced by estrogen, which may result in a deficiency.
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Fantastic new books! CAM Therapies has studies on natural therapies for over 100 diseases. CAM Labs lists lab tests for 100 diseases. Nutritional Genetics is a fantastic resource.
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