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Propiomazine, Largon Description Propiomazine (Largon) is an atypical antipsychotic phenothiazine derivative, which is used to treat negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation and psychotic symptoms in dementia. Action phenothiazine antipsychotic Indications Side Effects Xerostomia, hypertension or hypotension, sinus tachycardia. Drug-Vitamin-Herb Interactions Negative interactions: Kava Kava may block dopamine worsening movement disorder side effects, may cause excess sedation. Phenylalanine Phenylalanine may worssen the side effect of tardive dyskinesia associated with antipsychotic medications. St JohnÕs Wort St JohnÕs Wort accelerates breakdown of olanzapine (Zyprexa) and clozapine (Clozaril). St JohnÕs Wort and Dong quai St JohnÕs Wort and Dong quai can cause sensitivity to sun, adding to the side effects of antipsychotic agents. Sedative herbs: Kava, Passionflower, Hops, Ashwagandha, Calendula, Catnip, LadyÕs Slipper, Lemon Balm, Sassafras, Skullcap, and Yerba mansa. Sedative herbs may cause excess sedation when used with antipsychotic agents. Yohimbe Phenothiazines may increase yohimbe toxicity. Positive interactions: Coenzyme Q10 Phenothiazines inhibit enzymes containing CoQ10. Ginkgo biloba Ginkgo may help reduce side effects and increase efficacy of antipsychotic medications. Milk Thistle Milk Thistle may protect the liver against toxicity caused by phenothiazide drugs. Vitamin E Vitamin E may help treat and prevent tardive dyskenisia (a side effect of phenothiazide drugs).
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