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| Sinemet, Levodopa with Carbodopa Description Sinemet is Levodopa with Carbodopa. Levodopa converts to dopamine. Action levodopa converts to dopamine Indications ParkinsonÕs disease Side Effects anorexia, ataxia, dystonia, flushing, hypertension, hyperventilation, involuntary movements, leukopenia, nausea/vomiting, neuroleptic malignant syndrome, orthostatic hypotension, polyuria, psychosis, tremor, urinary incontinence, urinary retention, weight loss, Drug-Vitamin-Herb Interactions Negative interactions: 5-HTP The combination of 5-HTP and carbidopa may cause a scleroderma-like condition. Branched Chain Amino Acids, BCAAs Amino acids in dietary proteins decrease effectiveness of levodopa. Iron Iron interferes with absorption of carbodopa and levodopa. Take at separate times. Kava Kava may interfere with the action of dopamine. Vitamin B6 Higher doses of Vitamin B6 can reduce the therapeutic effect of levodopa alone in ParkinsonÕs disease. Mixed interactions: SAMe Levodopa may deplete SAMe.
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