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| Trimethoprim, Trimethoprim-Sulfamethazone, TMP-SMZ, Bactrim, Cotrim, Septra Description Trimethoprim-Sulfamethazone is an antibiotic combination that interferes with folate metabolism Action antibiotic combination, interfere with folate Indications Side Effects agranulocytosis, anorexia, aplastic anemia, bullous rash, crystalluria, diarrhea, dizziness, elevated hepatic enzymes, erythema nodosum, glossitis, headache, hematuria, hemolytic anemia, hepatic necrosis, hepatitis, hyperkalemia, interstitial nephritis, jaundice, leukopenia, maculopapular rash, methemoglobinemia, nausea/vomiting, neutropenia, pancreatitis, pancytopenia, photosensitivity, purpura, renal tubular necrosis, Stevens-Johnson syndrome, stomatitis, toxic epidermal necrolysis, urticaria, Drug-Vitamin-Herb Interactions Negative interactions: PABA PABA isused by bacteria to make folate. TMP-SMZ blocks bacterial folate production. Potassium TMP-SMZ may increase potassium levels which may cause hyperkalemia. St JohnÕs Wort and Dong Quai St JohnÕs Wort and Dong Quai can cause sensitivity to sunlight adding to drug side effects. Positive interactions: Lactobacillus acidophilus Probiotics replace normal intestinal bacteria, which may reduce the side effect of diarrhea associated with antibiotics. Sacchromyces boulardii Sacchromyces boulardii may prevent antibiotic-related diarrhea. Vitamin K Antibiotics may cause vitamin K deficiency by destroying the beneficial bacteria that produce it. Folate TMP-SMZ blocks bacterial folate production, folate may be helpful if taken long-term. N-Acetyl cysteine N-Acetyl cysteine may help prevent side effects caused by long term use of TMP-SMZ.
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Fantastic new books! CAM Therapies has studies on natural therapies for over 100 diseases. CAM Labs lists lab tests for 100 diseases. Nutritional Genetics is a fantastic resource.
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