GABA, Gamma-Amino Butyric Acid

GABA, Gamma-Amino Butyric Acid

Mechanism
GABA inhibits neural cells from over-firing

Biochemistry
gamma-aminobutyrate -> gamma-aminobutyric acid
with glutamate decarboxylase (GAD) and pyridoxal phosphate
GABA -> succinic semialdehyde -> succinate (citric acid cycle)
with GABA transaminase (GABA-T) and pyridoxal phosphate

Therapeutics

stiff man syndrome
autoimmunity to GAD
characterized by fluctuating but progressive muscle rigidity and
painful muscle spasms

diabetes mellitus
IDDM is characterized by destruction of B cells
the most abundant autoantibodies are against GAD receptors
GABA-A, ionotropic, form chloride channels
GABA-B, metabotropic, act to increase potassium conductance

anxiety - used with niacinamide and inositol
GABA is used to calm the body

References
Ganong Physiology, page 96

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