Natural Health Research

Naturopathic Medicine
Health Quizzes

Alpha Lipoic Acid, Alpha-Lipoic Acid, Thioctic acid

Alpha-lipoic acid (LA), also known as thioctic acid, is an anti-oxidant. It can reduce the oxidized forms of vitamin C, glutathione, CoQ10 and alpha-tocopherol.

antioxidant, detoxification, supports the liver
reverses amanita poisoning

Diabetes mellitus

Conventional chemical synthesis of alpha-lipoic acid results in a 50/50 (racemic) mixture of its two optical isomers, R-alpha-lipoic acid (right optical isomer) and S-alpha-lipoic acid (left optical isomer). Only the R-form of alpha-lipoic acid is naturally occurring. Research comparing the efficacy of the two forms has produced data in favor of the R-form as being superior with respect to mitochondrial ATP synthesis, as the mitochondria appear to be more sensitive to the naturally occurring form. This initial research suggests that R-form alpha-lipoic acid may be 10 times more potent than its mirror isomer. In addition, when measuring plasma concentrations after oral administration of both forms, R-form alpha-lipoic acid has been measured at 40-50% higher than the S-form. Therefore, R-form lipoic acid may be a better value even though it is more expensive on a comparative milligram basis. Please note that R-form lipoic acid needs refrigeration.

The reduced form is known as dihydrolipoic acid (DHLA), while the oxidized form is known as Alpha-lipoic acid (LA).




Fantastic new books!

CAM Therapies has studies on natural therapies for over 100 diseases.

CAM Labs lists lab tests for 100 diseases.

Nutritional Genetics is a fantastic resource.




Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease, or prescribing any medication. If you have or suspect that you have a medical problem, promptly contact your health care provider. Information and statements on this site have not been evaluated by the Food and Drug Administration.